Tissue Sodium Na Magnetic Resonance Imaging of Tissue Sodium
نویسندگان
چکیده
Hypertension is linked to disturbed total-body sodium (Na ) regulation; however, measuring Na disposition in the body is difficult. We implemented Na magnetic resonance spectroscopy (Na-MR) and imaging technique (Na-MRI) at 9.4T for animals and 3T for humans to quantify Na content in skeletal muscle and skin. We compared Na-MRI data with actual tissue Na content measured by chemical analysis in animal and human tissue. We then quantified tissue Na content in normal humans and in patients with primary aldosteronism. We found a 29% increase in muscle Na content in patients with aldosteronism compared with normal women and men. This tissue Na was mobilized after successful treatment without accompanying weight loss. We suggest that, after further refinements, this tool could facilitate understanding the relationships between Na accumulation and hypertension. Furthermore, with additional technical advances, a future clinical use may be possible. (Hypertension. 2012;59:167-172.)
منابع مشابه
23Na magnetic resonance imaging-determined tissue sodium in healthy subjects and hypertensive patients.
High dietary salt intake is associated with hypertension; the prevalence of salt-sensitive hypertension increases with age. We hypothesized that tissue Na(+) might accumulate in hypertensive patients and that aging might be accompanied by Na(+) deposition in tissue. We implemented (23)Na magnetic resonance imaging to measure Na(+) content of soft tissues in vivo earlier, but had not studied ess...
متن کاملبررسی شدت نسبی سیگنال تصاویر Magnetic Resonance در بافت رترودیسکال و عضله پتریگوئید خارجی و رابطه آن با یافتههای Magnetic Resonance Imaging
Background and Aims: Disc displacement is the most common temporomandibular joint disorder and magnetic resonance imaging (MRI) is the gold standard in its diagnosis. This disorder can lead to changes in signal intensity of magnetic resonance (MR). The purpose of this study was evaluation of correlation between relative signal intensity of MR images of retrodiscal tissue, superior and inferior ...
متن کاملMeasuring human cardiac tissue sodium concentrations using surface coils, adiabatic excitation, and twisted projection imaging with minimal T2 losses.
PURPOSE To measure tissue sodium concentrations in the human heart with (23)Na MRI using a surface coil, thereby eliminating the effects of inhomogeneous excitation by surface coils and minimizing T(1) and T(2) relaxation. MATERIALS AND METHODS We combined fully relaxed, very short-echo, (23)Na twisted projection imaging (TPI) with adiabatic half passage (AHP) excitation and external referenc...
متن کاملQuantitative assessment of muscle injury by 23Na magnetic resonance imaging
BACKGROUND (23)Na magnetic resonance imaging ((23)Na-MRI) is able to measure Na(+) in vivo in humans and allows quantification of tissue sodium distribution. We now tested the utility of (23)Na-MRI technique in detecting and assessing sports-related acute muscular injury. CASE PRESENTATION We assessed tissue Na(+) of both lower legs with a 3T MRI scanner using a customized (23)Na knee coil. T...
متن کاملRegional and temporal variations in tissue sodium concentration during the acute stroke phase.
A technique for noninvasively quantifying the concentration of sodium ((23) Na) ions was applied to the study of ischemic stroke. (23) Na-magnetic resonance imaging techniques have shown considerable potential for measuring subtle changes in ischemic tissue, although studies to date have suffered primarily from poor signal/noise ratio. In this study, accurate quantification of tissue sodium con...
متن کامل